Labdanes: antifungal compounds isolates from the resinous exudate of Madia sativa against Phytophthora cinnamomi Rands.
Identifieur interne : 000135 ( Main/Exploration ); précédent : 000134; suivant : 000136Labdanes: antifungal compounds isolates from the resinous exudate of Madia sativa against Phytophthora cinnamomi Rands.
Auteurs : Katy Díaz [Chili] ; Javier Espinoza [Chili] ; Luis Espinoza [Chili] ; César González [Chili] ; Alejandro Madrid [Chili]Source :
- Natural product research [ 1478-6427 ] ; 2020.
Descripteurs français
- KwdFr :
- Antifongiques (isolement et purification), Antifongiques (pharmacologie), Asteraceae (composition chimique), Diterpènes (isolement et purification), Diterpènes (pharmacologie), Phytophthora (effets des médicaments et des substances chimiques), Résines végétales (composition chimique), Structure moléculaire (MeSH).
- MESH :
- composition chimique : Asteraceae, Résines végétales.
- effets des médicaments et des substances chimiques : Phytophthora.
- isolement et purification : Antifongiques, Diterpènes.
- pharmacologie : Antifongiques, Diterpènes.
- Structure moléculaire.
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Resins, Plant.
- chemical , isolation & purification : Antifungal Agents, Diterpenes.
- chemical , pharmacology : Antifungal Agents, Diterpenes.
- chemistry : Asteraceae.
- drug effects : Phytophthora.
- Molecular Structure.
Abstract
In this study, resinous exudate from Madia sativa was analyzed by GC-MS. The major bioactive compounds 13,14,15-trihydroxylabd-7-ene (14) and 3,14,15-trihydroxylabd-8-ene (15) were isolated and their structures were determined by NMR. The antifungal activity of the resinous exudate and the labdanes compounds was evaluated using the inhibitory effects on the mycelial growth of plant pathogen Phytophthora cinnamomi causing root rot of various crops. The evaluation of the resinous exudate showed no inhibition over 50% at 75 mg/L, while compound 15 had the stronger effect on the myceliar growth of P. cinnamomi, with a 94.6% inhibition at 175 mg/L. The same way, the mixture of both compounds in equal parts did not show a synergistic effect but showed similar percentages of mycelial growth inhibition from 25 mg/L with respect to the compounds separately.
DOI: 10.1080/14786419.2018.1531402
PubMed: 30585076
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Labdanes: antifungal compounds isolates from the resinous exudate of <i>Madia sativa</i> against <i>Phytophthora cinnamomi</i> Rands.</title><author><name sortKey="Diaz, Katy" sort="Diaz, Katy" uniqKey="Diaz K" first="Katy" last="Díaz">Katy Díaz</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso</wicri:regionArea><wicri:noRegion>Valparaíso</wicri:noRegion></affiliation></author><author><name sortKey="Espinoza, Javier" sort="Espinoza, Javier" uniqKey="Espinoza J" first="Javier" last="Espinoza">Javier Espinoza</name><affiliation wicri:level="1"><nlm:affiliation>Universidad Andrés Bello, Viña del Mar, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Universidad Andrés Bello, Viña del Mar</wicri:regionArea><wicri:noRegion>Viña del Mar</wicri:noRegion></affiliation></author><author><name sortKey="Espinoza, Luis" sort="Espinoza, Luis" uniqKey="Espinoza L" first="Luis" last="Espinoza">Luis Espinoza</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso</wicri:regionArea><wicri:noRegion>Valparaíso</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Cesar" sort="Gonzalez, Cesar" uniqKey="Gonzalez C" first="César" last="González">César González</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso</wicri:regionArea><wicri:noRegion>Valparaíso</wicri:noRegion></affiliation></author><author><name sortKey="Madrid, Alejandro" sort="Madrid, Alejandro" uniqKey="Madrid A" first="Alejandro" last="Madrid">Alejandro Madrid</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Playa Ancha, Valparaíso, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Playa Ancha, Valparaíso</wicri:regionArea><wicri:noRegion>Valparaíso</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:30585076</idno><idno type="pmid">30585076</idno><idno type="doi">10.1080/14786419.2018.1531402</idno><idno type="wicri:Area/Main/Corpus">000587</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000587</idno><idno type="wicri:Area/Main/Curation">000587</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000587</idno><idno type="wicri:Area/Main/Exploration">000587</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Labdanes: antifungal compounds isolates from the resinous exudate of <i>Madia sativa</i> against <i>Phytophthora cinnamomi</i> Rands.</title><author><name sortKey="Diaz, Katy" sort="Diaz, Katy" uniqKey="Diaz K" first="Katy" last="Díaz">Katy Díaz</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso</wicri:regionArea><wicri:noRegion>Valparaíso</wicri:noRegion></affiliation></author><author><name sortKey="Espinoza, Javier" sort="Espinoza, Javier" uniqKey="Espinoza J" first="Javier" last="Espinoza">Javier Espinoza</name><affiliation wicri:level="1"><nlm:affiliation>Universidad Andrés Bello, Viña del Mar, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Universidad Andrés Bello, Viña del Mar</wicri:regionArea><wicri:noRegion>Viña del Mar</wicri:noRegion></affiliation></author><author><name sortKey="Espinoza, Luis" sort="Espinoza, Luis" uniqKey="Espinoza L" first="Luis" last="Espinoza">Luis Espinoza</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso</wicri:regionArea><wicri:noRegion>Valparaíso</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Cesar" sort="Gonzalez, Cesar" uniqKey="Gonzalez C" first="César" last="González">César González</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso</wicri:regionArea><wicri:noRegion>Valparaíso</wicri:noRegion></affiliation></author><author><name sortKey="Madrid, Alejandro" sort="Madrid, Alejandro" uniqKey="Madrid A" first="Alejandro" last="Madrid">Alejandro Madrid</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Playa Ancha, Valparaíso, Chile.</nlm:affiliation><country xml:lang="fr">Chili</country><wicri:regionArea>Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Playa Ancha, Valparaíso</wicri:regionArea><wicri:noRegion>Valparaíso</wicri:noRegion></affiliation></author></analytic><series><title level="j">Natural product research</title><idno type="eISSN">1478-6427</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antifungal Agents (isolation & purification)</term><term>Antifungal Agents (pharmacology)</term><term>Asteraceae (chemistry)</term><term>Diterpenes (isolation & purification)</term><term>Diterpenes (pharmacology)</term><term>Molecular Structure (MeSH)</term><term>Phytophthora (drug effects)</term><term>Resins, Plant (chemistry)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antifongiques (isolement et purification)</term><term>Antifongiques (pharmacologie)</term><term>Asteraceae (composition chimique)</term><term>Diterpènes (isolement et purification)</term><term>Diterpènes (pharmacologie)</term><term>Phytophthora (effets des médicaments et des substances chimiques)</term><term>Résines végétales (composition chimique)</term><term>Structure moléculaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Resins, Plant</term></keywords><keywords scheme="MESH" type="chemical" qualifier="isolation & purification" xml:lang="en"><term>Antifungal Agents</term><term>Diterpenes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antifungal Agents</term><term>Diterpenes</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Asteraceae</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Asteraceae</term><term>Résines végétales</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Phytophthora</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Antifongiques</term><term>Diterpènes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antifongiques</term><term>Diterpènes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Molecular Structure</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Structure moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, resinous exudate from <i>Madia sativa</i> was analyzed by GC-MS. The major bioactive compounds 13,14,15-trihydroxylabd-7-ene (<b>14</b>) and 3,14,15-trihydroxylabd-8-ene (<b>15</b>) were isolated and their structures were determined by NMR. The antifungal activity of the resinous exudate and the labdanes compounds was evaluated using the inhibitory effects on the mycelial growth of plant pathogen <i>Phytophthora cinnamomi</i> causing root rot of various crops. The evaluation of the resinous exudate showed no inhibition over 50% at 75 mg/L, while compound <b>15</b> had the stronger effect on the myceliar growth of <i>P. cinnamomi</i>, with a 94.6% inhibition at 175 mg/L. The same way, the mixture of both compounds in equal parts did not show a synergistic effect but showed similar percentages of mycelial growth inhibition from 25 mg/L with respect to the compounds separately.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">30585076</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>11</Day></DateCompleted><DateRevised><Year>2020</Year><Month>09</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1478-6427</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>16</Issue><PubDate><Year>2020</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Natural product research</Title><ISOAbbreviation>Nat Prod Res</ISOAbbreviation></Journal><ArticleTitle>Labdanes: antifungal compounds isolates from the resinous exudate of <i>Madia sativa</i> against <i>Phytophthora cinnamomi</i> Rands.</ArticleTitle><Pagination><MedlinePgn>2310-2314</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/14786419.2018.1531402</ELocationID><Abstract><AbstractText>In this study, resinous exudate from <i>Madia sativa</i> was analyzed by GC-MS. The major bioactive compounds 13,14,15-trihydroxylabd-7-ene (<b>14</b>) and 3,14,15-trihydroxylabd-8-ene (<b>15</b>) were isolated and their structures were determined by NMR. The antifungal activity of the resinous exudate and the labdanes compounds was evaluated using the inhibitory effects on the mycelial growth of plant pathogen <i>Phytophthora cinnamomi</i> causing root rot of various crops. The evaluation of the resinous exudate showed no inhibition over 50% at 75 mg/L, while compound <b>15</b> had the stronger effect on the myceliar growth of <i>P. cinnamomi</i>, with a 94.6% inhibition at 175 mg/L. The same way, the mixture of both compounds in equal parts did not show a synergistic effect but showed similar percentages of mycelial growth inhibition from 25 mg/L with respect to the compounds separately.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Díaz</LastName><ForeName>Katy</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Espinoza</LastName><ForeName>Javier</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Universidad Andrés Bello, Viña del Mar, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Espinoza</LastName><ForeName>Luis</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>González</LastName><ForeName>César</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Departamento de Química, Universidad Técnica Federico Santa María, Valparaíso, Chile.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Madrid</LastName><ForeName>Alejandro</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Playa Ancha, Valparaíso, Chile.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Prod Res</MedlineTA><NlmUniqueID>101167924</NlmUniqueID><ISSNLinking>1478-6419</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000935">Antifungal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004224">Diterpenes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012116">Resins, Plant</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000935" MajorTopicYN="N">Antifungal Agents</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019659" MajorTopicYN="N">Asteraceae</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004224" MajorTopicYN="N">Diterpenes</DescriptorName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010838" MajorTopicYN="N">Phytophthora</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012116" MajorTopicYN="N">Resins, Plant</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N"> Phytophthora cinnamomi </Keyword><Keyword MajorTopicYN="N">Madia sativa</Keyword><Keyword MajorTopicYN="N">labdanes</Keyword><Keyword MajorTopicYN="N">resinous exudate</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>9</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>12</Month><Day>27</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30585076</ArticleId><ArticleId IdType="doi">10.1080/14786419.2018.1531402</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Chili</li></country></list><tree><country name="Chili"><noRegion><name sortKey="Diaz, Katy" sort="Diaz, Katy" uniqKey="Diaz K" first="Katy" last="Díaz">Katy Díaz</name></noRegion><name sortKey="Espinoza, Javier" sort="Espinoza, Javier" uniqKey="Espinoza J" first="Javier" last="Espinoza">Javier Espinoza</name><name sortKey="Espinoza, Luis" sort="Espinoza, Luis" uniqKey="Espinoza L" first="Luis" last="Espinoza">Luis Espinoza</name><name sortKey="Gonzalez, Cesar" sort="Gonzalez, Cesar" uniqKey="Gonzalez C" first="César" last="González">César González</name><name sortKey="Madrid, Alejandro" sort="Madrid, Alejandro" uniqKey="Madrid A" first="Alejandro" last="Madrid">Alejandro Madrid</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Bois/explor/PhytophthoraV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000135 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000135 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Bois
|area= PhytophthoraV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:30585076
|texte= Labdanes: antifungal compounds isolates from the resinous exudate of Madia sativa against Phytophthora cinnamomi Rands.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30585076" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PhytophthoraV1
| This area was generated with Dilib version V0.6.38. |  |